dgrA [2017-03-21 15:27:05]

c-di-GMP receptor protein, inhibits motility at high c-di-GMP concentrations

locus: BSU22910

pI: 7.88

mw: 24.00 kDa

protein length: 217 aa

gene length: 651 bp

function: control of MotA activity

product: c-di-GMP receptor protein

essential: no

synonyms: ypfA,jofA

Genomic Context

Gene

Coordinates on the chromosome (coding sequence): 2,397,019 -> 2,397,672

The protein

Catalyzed reaction/ biological activity

• [dddd]

[SW|Domains]

• contains a C-terminal PilZ domain [Pubmed|22821967]

[SW|Cofactors]

• c-di-GMP [Pubmed|22821967]

Effectors of protein activity

• binding of c-di-GMP stimulates the inhibitory interaction with [protein|86C729C7D5ABEE519ADC4A893940600BBB655EF1|MotA] [Pubmed|22821967]

Expression and Regulation: [[this]]

categories

• [category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.2|Targets of c-di-GMP]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.5|Additional chemotaxis signal transduction and regulatory proteins]

Biological materials

Mutant

• MGNA-A419 (ypfA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/419 NBRP B. subtilis, Japan]

References

Reviews

• 25251856

Original Publications

• 23893111,22821967